PF-04449613 是一种选择性 PDE9A 抑制剂，IC50 为 22 nM。
货号:ajcx23258
CAS:1236858-52-8
分子式:C21H25N5O3
分子量：395.5
溶解度:DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC₅₀= 22 nM).¹It is selective for PDE9A over PDE1C (IC₅₀= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 µM but does inhibit the human dopamine transporter (DAT; K_i= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-04449613 (10 mg/kg) increases the rate of dendritic spine formation and elimination in mouse primary motor cortex pyramidal neuronsin vivo.²It increases the average running speed of mice in an accelerating rotarod task, indicating improved motor learning, at the same dose.

1.Claffey, M.M., Helal, C.J., Verhoest, P.R., et al.Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitorsJ. Med. Chem.55(21)9055-9068(2012) 2.Lai, B., Li, M., Hu, A., et al.The phosphodiesterase 9 inhibitor PF-04449613 promotes dendritic spine formation and performance improvement after motor learningDev. Neurobiol.78(9)859-872(2018)