C4H9NO3
货号:ajcx20942
CAS:7013-07-2
分子式:C4H9NO3
分子量：119.1
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-4-Amino-3-hydroxybutyric acid is a GABA receptor modulator.¹It binds to GABA_Aand GABA_Breceptors (IC₅₀s = 1 and 0.35 µM, respectively) and inhibits GABA uptake in rat brain synaptosomes (IC₅₀= 67 µM). (R)-4-amino-3-hydroxybutyric acid is also a GABA_Creceptor agonist that induces currents in a patch-clamp assay usingXenopusoocytes expressing the human receptor (EC₅₀= 19 µM).²In vivo, (R)-4-amino-3-hydroxybutyric acid (20 mg/animal) inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures.³

1.Falch, E., Hedegaard, A., Nielsen, L., et al.Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparationsJ. Neurochem.47(3)898-903(1986) 2.Hinton, T., Chebib, M., and Johnston, G.A.R.Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABAC receptorsBioorg. Med. Chem. Lett.18(1)402-404(2008) 3.Katayama, Y., and Mori, A.Inhibitory action of (3R)-(-)-4-amino-3-hydroxybutanoic acid on N-amidinobenzamide induced seizure activity in cat brainIRCS Med. Sci.5(9)437(1977)