COQ7-IN-2 (compound 12) 是 COQ7 的抑制剂，对 DMQ10 和 UQ10 积聚的 IC50 值分别为 7.3 μM 和 15.4 μM。
货号:ajcx34638
CAS:2579696-76-5
分子式:C15H13N3O
分子量：251.28
溶解度:DMSO : 25 mg/mL (99.49 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively[1].

COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells[1].The substantial DMQ10 accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))[1].

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182.