(E/Z)-GO289 是一种有效且选择性的酪蛋白激酶 2 (CK2) 抑制剂 (IC50=7 nM)。(E/Z)-GO289 强烈延长昼夜节律周期。(E/Z)-GO289 表现出与细胞时钟功能相关的对癌细胞生长的细胞类型依赖性抑制。
货号:ajcx34312
CAS:694522-87-7
分子式:C17H15BrN4O2S
分子量：419.3
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1]. (E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].

[1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.