MCC7840 sodium，一种磺酰脲类，是一种有效和选择性的 NLRP3 炎症小体 (NLRP3 inflammasome) 抑制剂，IC50 值小于 100 nM。MCC7840 sodium 可用于炎性疾病的研究。
货号:ajcx33754
CAS:2380032-29-9
分子式:C19H23N4NaO3S
分子量：410.47
溶解度:DMSO : 240 mg/mL (584.70 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of<100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2].

MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of<100 nM[1].

MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng•h/mL) and CL (0.621 mL/min/kg) in mice[2].MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].

[1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533.
[2]. O’neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.