Afatinibimpurity11是Afatinib的一种杂质，Afatinib是一种不可逆的EGFR家族抑制剂，抑制EGFRwt，EGFRL858R，EGFRL858R/T790M和HER2的IC50分别为0.5nM，0.4nM，10nM和14nM。
货号:ajcx30130
CAS:1402086-20-7
分子式:C21H18ClFN4O3
分子量：428.84
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.