IM156(HL156A)是二甲双胍的化学衍生物，是一种强效的AMPK激活剂。IM156在动物模型中可缓解与年龄相关的认知障碍。
货号:ajcx29414
CAS:1422365-94-3
分子式:C15H20F3N5O3
分子量：375.35
溶解度:DMSO: 100 mg/mL (266.42 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IM156 (HL156A), a chemical derivative of metformin , is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model[1][2].

IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1].IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1]. Western Blot Analysis[1] Cell Line: NIH3T3 cells

IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2].IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].IM156 significantly increases AMPK activation in the hippocampus of aged mice[2]. Animal Model: C57BL/6J mice (young group/12~16 weeks, old groups/20~22 months)[2]

[1]. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9. [2]. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.