An internal standard for the quantification of acyclovir
货号:ajcx21612
CAS:1185179-33-2
分子式:C8H7D4N5O3
分子量：229.2
溶解度:DMSO: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Acyclovir-d₄is intended for use as an internal standard for the quantification of acyclovir by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activityin vitroagainst the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID₅₀s = 0.1-63.1 μM).¹It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.²Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.³

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