PROTAC RAR Degrader-1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	902.13

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

PROTACRARDegrader-1包含cIAP1配体结合基团，linker和RAR配体结合基团。在HT1080细胞中，PROTACRARDegrader-1降低RAR水平，30μM浓度时达到最大降解程度。同时，基于cIAP1的降解剂也被称为SNIPER。
货号:ajcx13622
CAS:N/A
分子式:C50H71N5O10
分子量：902.13
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.