3-O-MethyldopaD3(3-Methoxy-L-tyrosineD3)是3-O-Methyldopa的氘代物。3-O-Methyldopa是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。
货号:ajcx30010
CAS:586954-09-8
分子式:C10H10D3NO4
分子量：214.23
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

[1]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52.