SPR719(VXc-486)是一种旋转酶B抑制剂，具有杀菌活性。VXc-486能有效抑制结核分枝杆菌的多种药敏菌株和耐药菌株，MIC分别为0.03-0.30μg/ml和0.08-5.48μg/ml。
货号:ajcx31498
CAS:1384984-18-2
分子式:C21H25FN6O3
分子量：428.46
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SPR719 (VXc-486) is a gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively[1].

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.