Pomalidomide-PEG1-C2-N3是一种合成的E3连接酶配体-linker偶联物，包含基于Pomalidomide的cereblon配体和1个单元PEG的linker。Pomalidomide-PEG1-C2-N3可通过PROTAC技术合成选择性的CDK6降解剂CP-10。CP-10诱导CDK6降解，DC50为2.1nM。
货号:ajcx31326
CAS:2271036-44-1
分子式:C17H18N6O5
分子量：386.36
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.