| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 4118元 |
| 分子量: | 377.9 |
Background:
Berberine-d6is intended for use as an internal standard for the quantification of berberine by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found inC. fenestratumand has diverse biological activities.1,2,3,4,5It induces frameshift mutations and gene crossovers in haploid and diploid strains ofS. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.2Berberine is active against theS. aureusstrains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).3It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.4Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.5
1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Pasqual, M.S., Lauer, C.P., Moyna, P., et al.Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organismsMutat. Res.286(2)243-252(1993) 3.Iwasa, K., Kamigauchi, M., Ueki, M., et al.Antibacterial activity and structure-activity relationships of berberine analogsEur. J. Med. Chem.31(6)469-478(1996) 4.Chen, C.C., Hung, T.H., Lee, C.Y., et al.Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injuryPLoS One9(12)e115694(2014) 5.Kong, W., Wei, J., Abidi, P., et al.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat. Med.10(12)1344-1351(2004)
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