Difelikefalin(CR-845;FE-202845)是周边限制性的，选择性的κ阿片受体(KOR)激动剂。Difelikefalin具有抗炎作用，并在慢性肾脏病等疾病中具有调节瘙痒的潜力。
货号:ajcx29288
CAS:1024828-77-0
分子式:C36H53N7O6
分子量：679.85
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].

[1]. Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5(5):600-610. [2]. Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382(3):222-232.