Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM).
货号:ajcx18032
CAS:N/A
分子式:C20H31N5O10S•XCF3COOH
分子量：533.6
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord.