Deserpidine (Harmonyl) 是与 Reserpine 相关的从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 被用作抗高血压药和镇定剂。Deserpidine 是一种竞争性血管紧张素转化酶 (ACE) 抑制剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。
货号:ajcx15320
CAS:131-01-1
分子式:C32H38N2O8
分子量：578.65
溶解度:DMSO: 100 mg/mL (172.82 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex[1][2][3].

Deserpidine is an effective ganglionic blocking agent, which differs from Reserpine only by the absence of a methoxy group at C-11. Deserpidine has been used in the treatment of hypertension and psychosis. In addition, Deserpidine appears to act as a controller of other cardiac disorders[1][2].

[1]. Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68(11):1629-31. [2]. Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3221-5. [3]. Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35(14):2558-62.