BT18 是一种功能类似于胶质细胞源神经营养因子 (GDNF) 的分子模拟物。BT18 影响 GDNF 家族受体 GFRα1 和 RET 受体酪氨酸激酶 RetA 的功能。
货号:ajcx38824
CAS:924811-53-0
分子式:C30H31F4N3O6S
分子量：637.64
溶解度:DMSO : 100 mg/mL (156.83 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1].

[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.
[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414.