An internal standard for the quantification of olsalazine
货号:ajcx25174
CAS:N/A
分子式:C8[13C]6H10N2O6
分子量：308.2
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Olsalazine-¹³C₆is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.¹In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED₅₀= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM.^2,3Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B₄levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate .⁴Olsalazine also inhibits bovine xanthine oxidasein vitro(IC₅₀= 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid when administered at a dose of 20 mg/kg.⁵Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.

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