Abametapir 是一种金属蛋白酶 (MMP) 抑制剂，能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
货号:ajcx21578
CAS:1762-34-1
分子式:C12H12N2
分子量：184.2
溶解度:DMF: 15mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Abametapir is a building block and an insectide.^1,2,3It has been used in the synthesis of lanthanide coordination complexes with antifungal activity againstC. albicansand divalent vancomycin derivatives with antibacterial activity against vancomycin-resistant enterococci.^1,2Abametapir is ovicidal to DDT- and permethrin-resistant head louse eggs (LC₅₀s = 0.108, 0.121, and 0.16% in isopropanol for 0-2-, 3-5-, and 6-8-day-old eggs, respectively).³Formulations containing abametapir have been used in the topical treatment of head lice infestation.

1.Zhou, M.-X., Ren, N., Zhang, J.-J., et al.Synthesis, crystal structure, thermal, luminescent property and antibacterial activity of lanthanide ternary complexes with p-chlorobenzoic acid and 5,5′-dimethyl-2,2′-bipyridineJ. Mol. Struct.1200127049(2020) 2.Xing, B., Yu, C.-W., Ho, P.-L., et al.Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococciJ. Med. Chem.46(23)4904-4909(2003) 3.Bowles, V.M., Yoon, K.S., Barker, S.C., et al.Ovicidal efficacy of abametapir against eggs of human head and body lice (Anoplura: Pediculidae)J. Med. Entomol.54(1)167-172(2017)