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Oxonic Acid-13C2,15N3(potassium salt hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxonic Acid-13C2,15N3(potassium salt hydrate)图片
包装:1mg
规格:98%
市场价:3689元
分子量:200.1

产品介绍
C2[13C]2H2[15N]3O4•K [XH2O]
货号:ajcx24868
CAS:N/A
分子式:C2[13C]2H2[15N]3O4•K [XH2O]
分子量:200.1
溶解度:Water: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Oxonic acid-13C2,15N3is intended for use as an internal standard for the quantification of oxonic acid (potassium salt) by GC- or LC-MS. Oxonic acid is a uricase inhibitor (IC50= 0.8 µM) that prevents metabolism and excretion of uric acid.1,2It also inhibits orotate phosphoribosyltransferase (ORPT), reducing OPRT-mediated phosphorylation of 5-fluorouracil in Yoshida sarcoma cell extracts with an IC50value of 3.7 µM.3Oxonic acid (10-50 mg/kg) decreases the severity of gastrointestinal tract injury and the incidence of diarrhea induced by the 5-FU prodrug tegafur and uracil without loss of antitumor activity in a rat Yoshida sarcoma model. It has also been used to induce hyperuricemia in rodents.4Formulations containing oxonic acid have been used in the treatment of head, neck, lung, pancreatic, gastric, and breast carcinomas.


1.Johnson, W.J., and Chartrand, A.Allantoxanamide: A potent new uricase inhibitor in vivoLife Sci.23(22)2239-2244(1978) 2.Gralla, E.J., and Crelin, E.S.Oxonic acid and fetal development: I. Embryotoxicity in miceToxicology6(3)289-297(1976) 3.Shirasaka, T., Shimamoto, Y., and Fukushima, M.Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in ratsCancer Res.53(17)4004-4009(1993) 4.Stavric, B., and Nera, E.A.Use of the uricase-inhibited rat as an animal model in toxicologyClin. Toxicol.13(1)47-74(1978)