Glutamine-rich 1 is a 776 amino acid protein containing one CARD domain, which is normally found in proteins that are related to inflammation and apoptosis processes. CARD domains are found in a wide variety of proteins including kinases, caspases, and helicases. The gene encoding Glutamine-rich 1 maps to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.