HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor which reduces Pim kinase-induced myosin phosphorylation and the contractility of vascular smooth muscle in spontaneously hypertensive RenTG mice. References: Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25(10):1195-1207.e32. doi: 10.1016/j.chembiol.2018.06.006. Epub 2018 Jul 19. PubMed PMID: 30033129.
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CAS:922050-57-5