B-Raf IN 10

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B-Raf IN 10

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1425485-87-5

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

B-Raf IN 10 (Compound C09) 是一种 BRAF 抑制剂，IC50 在 50-100 nM。B-Raf IN 10 具有抗肿瘤活性。

Cas No.

1425485-87-5

分子式

C₂₂H₂₁F₃N₄O₄S

分子量

494.49

溶解度

DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C)

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

B-Raf IN 10 (Compound C09) is aBRAFinhibitor with anIC₅₀between 50 and 100 nM. B-Raf IN 10 shows antitumor activity^[1].

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E^[1].
B-Raf IN 10 shows an IC₅₀between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E^[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells^[1].

Cell Viability Assay^[1]

Cell Line:	A375, SK-MEL-28, SK-MEL-31 and CHL-1
Concentration:
Incubation Time:	72 h
Result:	Showed inhibition with IC₅₀s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.