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Indimitecan
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Indimitecan图片
CAS NO:915360-05-3
包装与价格：
包装价格(元)
10mg电议
25mg电议

产品介绍
Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
Cas No.915360-05-3
别名LMP776
分子式C25H21N3O6
分子量459.45
溶解度DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition[1].
Indimitecan can be substrates for metabolic ketone reductases[1].

Cell Proliferation Assay[1]

Cell Line:HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7
Concentration:0-100 μM
Incubation Time:
Result:Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute's developmental therapeutics assay (the "NCI60")) was 0.079 ± 0.023 μM.