| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Canonical SMILES | O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)[C@H]1CC2=CC=C(C=C2)O.OC(C(F)(F)F)=O |
| 分子式 | C27H41N9O8• XCF3COOH |
| 分子量 | 619.7 |
| 溶解度 | Ethanol: soluble,Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cyclo(RGDyK) is a cyclic peptide ligand of αVβ3 integrin (IC50= 37.5 nM) that contains the αVβ3 integrin-binding sequence arginine-glycine-aspartate (RGD).1It has been conjugated to radiolabels or fluorescent probes for the visualization of αVβ3-mediated neoangiogenesis or optical imaging of αVβ3-expressing tumors in live mice.2,1Cyclo(RGDyK) has also been conjugated to the DNA topoisomerase I inhibitor SN38 and an SN38-releasing trigger moiety to form a prodrug that targets cells overexpressing αVβ3 integrin and induces cytotoxicity in KB human cervical carcinoma cells.3 1.Chen, X., Conti, P.S., and Moats, R.A.In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenograftsCancer Res.64(21)8009-8014(2004) 2.van Hagen, P.M., Breeman, W.A., Bernard, H.F., et al.Evaluation of a radiolabelled cyclic DTPA-RGD analogue for tumour imaging and radionuclide therapyInt. J. Cancer90(4)186-198(2000) 3.Huang, B., Desai, A., Tang, S., et al.The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug releaseOrg. Lett.12(7)1384-1387(2010) |
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