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Rosuvastatin lactone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rosuvastatin lactone图片
CAS NO:503610-43-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
The lactone form of rosuvastatin
Cas No.503610-43-3
别名瑞舒伐他汀-5S-内酯
Canonical SMILESO[C@@H](CC(O1)=O)C[C@H]1/C=C/C2=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C2C3=CC=C(C=C3)F
分子式C22H26FN3O5S
分子量463.5
溶解度DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin .1It is foundin vivofollowing rosuvastatin administration.2Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 µM, respectively).1

1.Shiozawa, A., Yamaori, S., Kamijo, S., et al.Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)Drug Metab. Pharmacokinet.36100364(2021) 2.Martin, P.D., Warwick, M.J., Dane, A.L., et al.Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteersClin. Ther.25(11)2822-2835(2003)