硫代秋水仙碱，一种在秋水仙碱 C 环中修饰的衍生物，具有增强的生物学特性。 Thiocolchicine 是一种有效的微管蛋白聚合抑制剂 (IC50=2.5 μM)，与微管蛋白竞争性结合，Ki 为 0.7 μM。硫代秋水仙碱诱导细胞凋亡。硫代秋水仙碱可用作 ADC 技术中的 ADC 细胞毒素。
| Cas No. | 2730-71-4 |
| 别名 | 硫代秋水仙碱 |
| Canonical SMILES | O=C1C(SC)=CC=C2C([C@@H](NC(C)=O)CCC3=C2C(OC)=C(OC)C(OC)=C3)=C1 |
| 分子式 | C22H25NO5S |
| 分子量 | 415.5 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM). |
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