| Cas No. | 696-06-0 |
| 别名 | 5-氟二氢嘧啶-2,4-二酮 |
| 化学名 | 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione |
| Canonical SMILES | O=C1NC(NCC1F)=O |
| 分子式 | C4H5FN2O2 |
| 分子量 | 132.1 |
| 溶解度 | DMF: 60 mg/ml,DMSO: 53 mg/ml,Ethanol: 0.8 mg/ml,PBS (pH 7.2): 8 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells). |
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