Asperosaponin VI

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Asperosaponin VI

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

39524-08-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
20mg	电议

产品介绍

AsperosaponinVI是来自续断壁的一种皂苷组分。AsperosaponinVI通过BMP-2/p38和ERK1/2信号途径诱导成骨细胞分化。AsperosaponinVI通过增加Bcl-2/Bax比值，降低活性caspase-3表达，以及增强p-Akt和p-CREB，从而抑制缺氧诱导的心肌细胞凋亡(apoptosis)。

Cas No.	39524-08-8
别名	川续断皂苷 VI
Canonical SMILES	O[C@@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2[C@@](C)(CO)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@@H]7O[C@H](CO[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H](O)[C@H](O)[C@H]7O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)OC1
分子式	C₄₇H₇₆O₁₈
分子量	929.1
溶解度	DMSO: 100 mg/mL (107.63 mM)
储存条件	-20°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB[2]. [1]. Niu Y, et al. Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res. 2011 Nov;25(11):1700-6. [2]. Li C, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7.