PROTAC Mcl1 degrader-1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2163793-38-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

PROTAC Mcl1 degrader-1 (compound C3) 是一种靶向嵌合体的蛋白水解 (PROTAC)，是有效，选择性的 Mcl-1 抑制剂，IC50 为 0.7 μM。PROTAC Mcl1 degrader-1 通过将具有微摩尔范围亲和力的 E3 连接酶脑 (CRBN) 结合配体 pomalidomide 引入 Mcl-1 抑制剂 S1-6 来诱导 Mcl-1 的泛素化和蛋白酶体降解。

Cas No.	2163793-38-0
Canonical SMILES	O=C(C1=CC=CC(NCCCCCCNC(CCCCC(NCCN2C(C3=C4C(C2=O)=CC=C(C4=CC=C3)SC5=CC=C(C=C5)Br)=O)=O)=O)=C1C6=O)N6C7CCC(NC7=O)=O
分子式	C₄₅H₄₅BrN₆O₈S
分子量	909.84
溶解度	DMSO: 50 mg/mL (54.95 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1]. [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.