从水稻栽培的 Talaromyces derxii 中分离得到的青霉胺 (Vermixocin A) 对酰基辅酶 A:胆固醇酰基转移酶 (ACAT) 具有抑制活性。
| Cas No. | 55303-92-9 |
| 别名 | Vermixocin A |
| Canonical SMILES | COC1=C2C(OC(C(O)=CC(C)=C3)=C3COC2=O)=CC=C1[C@@H](O)CC(C)C |
| 分子式 | C21H24O6 |
| 分子量 | 372.4 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 µM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 µM). It is also an antagonist of oxytocin receptors (IC50 = 67 µM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. |
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