| CAS NO: | 550-24-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 294.39 |
|---|---|
| Formula | C17H26O4 |
| CAS No. | 550-24-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 59 mg/mL (200.41 mM) |
| Water: <1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: 12 mg/mL (40.76 mM) | |
| Other info | Synonym: NSC91874; NSC91874; Embelin; Emberine; NSC 91874; Embelic acid. Chemical Name: 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione InChi Key: IRSFLDGTOHBADP-UHFFFAOYSA-N InChi Code: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3 SMILES Code: O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O |
| Chemical Name | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione |
| In Vitro | Embelin from the Japanese Ardisia herb is a small-molecular inhibitor that binds to the XIAP BIR3 domain with which Smac and caspsase-9 bind. Embelin inhibits cell growth of both PC-3 and LNCap cells in a dose-dependent manner, with IC50 values of 3.7 and 5.7 μM. While, the toxicity of Embelin in normal PrEC and in WI-38 cells is much lower with IC50 values of 20.1 μM and 19.3 μM. |
|---|---|
| In Vivo | Embelin has also been used extensively in various animal models to study the role of XIAP. In the azoxymethane/dextran sulfate sodium (AOM/DSS) induced colitis-associated cancer (CAC) model, embelin reduced both incidence and tumor size in mice by inhibiting proliferation of tumor epithelial cells and suppressing IL6 expression and IL6-activated STAT3 in vivo. |
| Animal model | AOM/DSS-induced colitis-associated cancer (CAC) model |
| Formulation & Dosage | 50 mg/kg/day; p.o. |
| References | Mol Cancer Ther 2014,13:1206-1216. |
 Oncol Lett. 2015 Aug;10(2):921-926. |
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