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α-Bisabolol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
α-Bisabolol图片
CAS NO:515-69-5
包装与价格：
包装价格(元)
500mg电议
1g电议

产品介绍
α-红没药醇是一种无毒的倍半萜醇，存在于天然精油中，具有抗癌活性。 α-红没药醇通过诱导细胞周期停滞、线粒体凋亡和抑制 PI3K/Akt 信号通路对 A549 NSCLC 细胞发挥选择性抗癌作用 (IC50=15 μM)。 α-红没药醇还强烈诱导胶质瘤细胞凋亡。
Cas No.515-69-5
别名alpha-红没药醇
Canonical SMILESC/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C
分子式C15H26O
分子量222.37
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].

[1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412. [2]. Cavalieri E, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004 Mar 12;315(3):589-94.