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DPM-1001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPM-1001图片
CAS NO:1471172-27-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
DPM-1001 是一种有效的,特异性的,口服生物可利用且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂,其 IC50 为 100 nM,特异性 PTP1B 抑制剂 MSI-1436 的类似物 (IC50=600 nM)。DPM-1001 具有抗糖尿病特性。
Cas No.1471172-27-6
Canonical SMILESO[C@H]1[C@]2([H])[C@@](CC[C@@]3(C)[C@@]2([H])CC[C@]3([H])[C@H](C)CCC(OC)=O)([H])[C@]4(C)[C@@](C[C@H](NCCCCNCC5=CC=CC=N5)CC4)([H])C1
分子式C35H57N3O3
分子量567.85
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].

[1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525.