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Direct Blue 1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Direct Blue 1图片
CAS NO:2610-05-1
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议

产品介绍
DirectBlue1(ChicagoSkyBlue6B)是免疫荧光组织化学中背景自体荧光的一种复染料。DirectBlue1在结构上与谷氨酸盐有关，是一种有效且具有竞争性的VGLUT抑制剂，不影响质膜转运体。DirectBlue1是第一个能够抑制Aβ结合的小分子PrP配体。
Cas No.2610-05-1
别名Chicago Sky Blue 6B
Canonical SMILESCOC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(OC)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5
分子式C34H24N6Na4O16S4
分子量992.8
溶解度DMSO: 125 mg/mL (125.91 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344. [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658. [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.