| CAS NO: | 288323-41-1 |
| 包装 | 价格(元) |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 281.5 |
| Cas No. | 288323-41-1 |
| Formula | C15H23NS2 |
| Solubility | ≤30mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | 2-(10-isothiocyanatodecyl)-thiophene |
| Canonical SMILES | S=C=NCCCCCCCCCCC1=CC=CS1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor [1].
The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].
Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes [1].
References:
[1] Yu R, Mandlekar S, Harvey K J, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[J]. Cancer Research, 1998, 58(3): 402-408.
[2] Nebert D W, Russell D W. Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.
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