Quinaldopeptin 是一种从 Streptoverticillium album 菌株培养物中分离出来的奎宁霉素抗生素，对革兰氏阳性菌和厌氧菌具有高度活性，对培养的 B16 黑色素瘤细胞具有很强的细胞毒性。
| Cas No. | 130743-07-6 |
| 别名 | 喹哪朵肽 |
| Canonical SMILES | O=C(CN(C)C(CNC([C@@]1([H])N(C([C@@](NC(C2=NC(C=CC=C3)=C3C=C2O)=O)([H])[C@H](C)NC([C@@]4([H])N5CCCC4)=O)=O)CCCC1)=O)=O)N(CCCC6)[C@]6([H])C(N[C@@H](C)[C@](NC(C7=NC(C=CC=C8)=C8C=C7O)=O)([H])C(N9CCCC[C@@]9([H])C(NCC(N(C)CC5=O)=O)=O)=O)=O |
| 分子式 | C62H78N14O14 |
| 分子量 | 1243.4 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 µg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 µg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM). |
m.cnreagent.com