360A is a selective stabilizer ofG-quadruplex, and also inhibitstelomeraseactivity with anIC₅₀of 300 nM fortelomerasein TRAP-G4 assay.

IC50: 300 nM (Telomerase)^[1]
G-quadruplex^[1]

360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC₅₀of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC₅₀s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively^[1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions^[2].

449.50

C₂₇H₂₃N₅O₂

794458-56-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.