PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibitsphosphatidylinositol-3phosphate 5-kinase (PIKfyve)withIC₅₀value of 6.9 nM. PIKfyve-IN-1 can be used for the research ofPIKfyvein virology^[1].

IC50: 6.9 nM (PIKfyve)^[1]

PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC₅₀values of 6.9 nM and 4.01 nM, respectively^[1].
PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry^[1].
PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC₅₀values of 23.5 nM and 19.5 nM, respectively^[1].
PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis^[1].

331.41

C₂₀H₂₁N₅

2857982-26-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.