VCP/p97 inhibitor-1 is a potent inhibitor ofVCP/p97(also called Cdc48, CDC-. 48, or Ter94) with anIC₅₀of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)^[1][2].

54.7 nM (VCP/p97)^[1]

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC₅₀s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively^[1].

491.37

C₂₄H₂₆BN₅O₄S

2630950-38-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.