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Cilastatin-15N,d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cilastatin-15N,d3图片
CAS NO:2738376-83-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
MK0791-15N,d3
产品介绍
Cilastatin-15N,d3 是一种 15N 标记和氘代标记的 Cilastatin。Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I (renal dehydropeptidase I) 抑制剂,IC50为 0.1 μM。Cilastatin 抑制细菌金属叶内酰胺酶CphAIC50为 178 μM。Cilastatin 可用作抗菌辅助剂。
生物活性

Cilastatin-15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits thebacterialmetallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[5].

分子量

362.46

性状

Solid

Formula

C16H23D3N15NO5S

CAS 号

2738376-83-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month