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(-)-Xestospongin C
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(-)-Xestospongin C图片
CAS NO:88903-69-9
包装与价格：
包装价格(元)
10ug电议
50ug电议
100ug电议
250ug电议

产品介绍
(-)-Xestospongin C ((-)-(-)-Xestospongin C) 是一种选择性、可逆的肌醇 1,4,5-三磷酸受体 (IP3R) 抑制剂。
Cas No.88903-69-9
别名XeC, Araguspongine E
化学名[1R-(1R,4aR,11R,12aS,13S,16aS,23R,24aS)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b1]dipyridine
Canonical SMILESN12[C@@H]([C@@H](CCCCCC[C@@H]3O[C@@H]4N(CC3)CCC[C@@H]4CCCCCC5)CCC2)O[C@@H]5CC1
分子式C28H50N2O2
分子量446.71
溶解度Slightly soluble in DMSO and Water
储存条件Desiccate at -20°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties.[1] Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 μM.[2] Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.[3]

Reference:
[1]. Nakagawa, M., and Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Letters 25(30), 3227-3230 (1984).
[2]. Gafni, J., Munsch, J.A., Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19, 723-733 (1997).
[3]. Castonguay, A., and Robitaille, R. Xestospongin C is a potent inhibitor of SERCA at a vertabrate synapse. Cell Calcium 32(1), 39-47 (2002).