Dictyostatin

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Dictyostatin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

156312-07-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

(-)-Dictyostatin
Dictyostatin 1

产品介绍

Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。

生物活性

Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potentmicrotubule stabilizingagent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies^[1]^[2]^[3].

体外研究
(In Vitro)

Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性^[2]。

Cell Viability Assay^[2]

Cell Line:	A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells
Concentration:	0-100 nM
Incubation Time:	72-120 h
Result:	Showed antiproliferative activity with GI₅₀s of 0.5, 5.1, 1.3, 18.8, 5.1 nM for A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells, respectively.

体内研究
(In Vivo)

Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良^[3]。

Animal Model:	6-month old male B6 PS19 tau Tg mice^[3]
Dosage:	0.3, 1 mg/kg
Administration:	I.p.; once-weekly for 3 months
Result:	Improved MT density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated PS19 mice, caused a significant reduction of insoluble TauAcK280.

分子量

532.75

Formula

C₃₂H₅₂O₆

CAS 号

156312-07-1

来源

Spongia

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.