Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is abacterialβ-lactamaseinhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins andother antibiotics. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin^[1][2].

Clavulanate potassium (2 μg/mL) is susceptive to β-lactamase-positive and β-lactamase-negativeBacteroidesspp. andFusobacteriumspp. with the combination of amoxicillin (4 μg/mL) and ticarcillin (64 μg/mL)^[1].
Clavulanate potassium (16 μg/mL) inhibitsB. intermedius,B. bivius,B. disiens,B. oris,B. buccae,B. buccalisandB. loescheiwith MIC₅₀values of 8 μg/mL^[1].
Clavulanate potassium (16 μg/mL) inhibitsB. melaninogenicus,B. oralisandF. variumwith MIC₅₀values of 16 μg/mL^[1].
Clavulanate potassium (2 μg/mL) raises amoxicillin susceptibility rates for β-lactamase-positiveBacteroidesspecies and fusobacteria from 41.3 to 90.8% and from 64.2 to 88.7%, respectively^[1].

Clavulanate potassium (125 mg; 20 d) protects 75% of mice with experimental pneumonitis compared with no survivors in the control group^[2].

238.26 (Potassiumclavulanate)

Solid

C₈H₉NO₅K .(C₆H₁₀O₅)n

克拉维酸钾:微晶纤维素 (1:1)

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 1 mg/mL(ultrasonic and warming and heat to 80℃)

H₂O :< 0.1 mg/mL(insoluble)