Antiparasitic agent-9 (compound 47) 是一种口服有效的抗寄生虫剂。Antiparasitic agent-9 显示对人类寄生虫的抗寄生虫活性。
| 生物活性 | Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the humanparasite[1]. |
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体内研究
(In Vivo) | Antiparasitic agent-9 (compound 47) (15 mg/kg, Orally, twice each day for 7 days) reduces adult worm burden in the jirdL. sigmodontisinfection model[1].
Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure[1].
Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse[1].
| PO (30 mg/kg) | PO (10 mg/kg) | IV (2 mg/kg) | | Cmax(μM) | 13.9 | 5.27 ± 0.83 | | | Tmax(h) | 0.50 | 4.0 ± 2.8 | | | AUC0-inf(μM·h) | 121 | 68.1±NC | | | CL (mL/min/kg) | | | 3.6 ± 0.22 | | Vd ss (mL/kg) | | | 0.74 ± 0.08 | | F (%) | | 57 | | | brain/plasma [b]/[p] | 0.08 | | | | efflux ratio (ER) | 12 | | |
| Animal Model: | Female BALB/c mice (infected withL. sigmodontis, 6-8 weeks)[1] | | Dosage: | 15 mg/kg | | Administration: | Orally, twice each day for 7 days | | Result: | Showed a significant worm burden reduction of 59% at 15 mg/kg. |
| Animal Model: | Male CD-1 mouse (n = 4)[1] | | Dosage: | 2 mg/kg (IV), 10 and 30 mg/kg (PO) | | Administration: | IV, PO, once (Pharmacokinetic Analysis) | | Result: | Showed a brain to plasma ratio of 0.08, suggesting limited brain exposure. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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