| CAS NO: | 119520-05-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 119520-05-7 |
| 别名 | 齐帕特罗,RU-42173,Zilmax? |
| 化学名 | (6R,7R)-rel-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one |
| Canonical SMILES | O=C1NC2=CC=CC3=C2N1CC[C@H](NC(C)C)[C@H]3O |
| 分子式 | C14H19N3O2 |
| 分子量 | 261.3 |
| 溶解度 | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Zilpaterol is a β-adrenergic receptor agonist. β-adrenergic receptors, prototypic G-protein-coupled receptors, play a key role in regulating numerous physiological processes. In vitro: Previus study found that there was no effect of zilpaterol (ZH) on thymidine incorporation into DNA. ZH at 1 μM could decrease β1-AR mRNA, and 0.01 and 1 μM ZH decreased β2-AR and β3-AR mRNA in myoblasts. There was no effect of ZH on the β-AR or IGF-I gene expression in fused myotube cultures. The β2-AR antagonist ICI-118, 551 attenuated the effect of ZH to reduce expression of β1- and β2-AR mRNA. There was no effect of ICI-118, 551 or ZH on β3-AR or IGF-I. In addition, the total lipid synthesis from acetate was increased by ZH in bovine subcutaneous adipose tissue explants in the absence of theophylline [1]. In vivo: FDA has approved label claims of increased rate of BW gain, improved feed efficiency, and increased carcass leanness. The feeding of ZH for 20 to 40 d with a 3-d withdrawal resulted in significantly increased ADG. Such increases equate to an average of 9 kg heavier BW in ZH-fed steers. Moreover, hot carcass weight has been shown to increase to a larger degree compared with BW, with an average improvement of 15 kg [2]. Clinical trial: So far, no clinical study has been conducted. References: |
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