OMDM-1 是一种强效、选择性和代谢稳定的 anandamide 细胞摄取 (ACU) 抑制剂，Ki 为 2.4 μM。
| Cas No. | 616884-62-9 |
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)N[C@H](CO)Cc1ccc(O)cc1 |
| 分子式 | C27H45NO3 |
| 分子量 | 431.7 |
| 溶解度 | Ethanol: 30 mg/ml,DMF: 30 mg/ml,DMSO: Miscible,DMSO:PBS (pH 7.2) (1:1): .5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Numerous analogs of arachidonoyl ethanolamide potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. OMDM-1 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA. Structurally, OMDM-1 is the amide of (S)-tyrosinol with oleic acid . In RBL-2H3 cells, OMDM-1 inhibits the cellular uptake of tritiated AEA with an IC50 of 2.4 µM, with negligible effects on the CB1 receptor and VR1. |
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