您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Cathepsin L Inhibitor
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Cathepsin L Inhibitor
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cathepsin L Inhibitor图片
CAS NO:167498-29-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Cathepsin L Inhibitor (Z-Phe-Tyr-CHO) 是一种有效的特异性组织蛋白酶 L (CTSL) 抑制剂。
Cas No.167498-29-5
别名SB 412515
化学名N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester
Canonical SMILESOC1=CC=C(C[C@@H](C=O)NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)C=C1
分子式C26H26N2O5
分子量446.5
溶解度20 mg/ml in DMSO, 20 mg/ml in DMF, 2 mg/ml in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM). [1] It is selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively). It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. [2] Cathepsin L inhibitor completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml., [1][3] In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner.

Reference:
[1]. Woo, J.-T., Sigeizumi, S., Yamaguchi, K., et al. Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L. Bioorganic Med. Chem. Lett. 5(14), 1501-1504 (1995).
[2]. Nkemngu, N.J., Grande, R., Hansell, E., et al. Improved trypanocidal activities of cathepsin L inhibitors. Int. J. Antimicrob. Agents 22(2), 155-159 (2003).
[3]. Woo, J.-T., Yamaguchi, K., Hayama, T., et al. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. Eur. J. Pharmacol. 300(1-2), 131-135 (1996).