Nitro-PDS-Tubulysin M is adrug-linker conjugate for ADCwith potent antitumor activity by using Tubulysin M (a tubulin polymerization inhibitor), linked via theADC linkerNitro-PDS.

ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.147 nM, and ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC₅₀s of 2.07 nM, 1.004 nM, respectively^[1].

1106.40

C₅₄H₇₃N₈O₁₁S₃

1941168-69-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.