CDK1-IN-3

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CDK1-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CDK1-IN-3 (8g) 是CDK1的选择性抑制剂，对 CDK1，CDK2 和 CDK5 的IC₅₀值分别为 36.8，305.17 和 369.37 nM。CDK1-IN-3 通过影响细胞周期抑制癌细胞的生长。CDK1-IN-3 可用于癌症的研究。

生物活性

CDK1-IN-3 (8g) is a selectiveCDK1inhibitor withIC₅₀s of 36.8, 305.17 and 369.37 nM forCDK1,CDK2andCDK5, respectively. CDK1-IN-3 inhibits the growth ofcancercells by affecting cell cycle. CDK1-IN-3 can be used for the research ofcancer^[1].

IC₅₀& Target

CDK1

36.8 nM (IC₅₀)

CDK2

305.17 nM (IC₅₀)

CDK5

369.37 nM (IC₅₀)

体外研究
(In Vitro)

CDK1-IN-3 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells^[1].
CDK1-IN-3 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC₅₀s of 36.8, 305.17 and 369.37 nM, respectively^[1].
CDK1-IN-3 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC₅₀s of 5655, 3632, 4626, 5265, 5514 and 2829 nM, respectively^[1].
CDK1-IN-3 (0.51 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle^[1].

Cell Proliferation Assay^[1]

Cell Line:	PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration:	0-10 μM
Incubation Time:	24 hours
Result:	Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cells over 61%, and inhibited MDA-PATC53 and PL45 cells with IC₅₀s of 0.51 and 0.74 μM, respectively.

Western Blot Analysis^[1]

Cell Line:	MDA-PATC53 cell line
Concentration:	0.51 μM
Incubation Time:	24 hours
Result:	Downregulated CDK1 protein level compared to untreated cells.

Western Blot Analysis^[1]

Cell Line:	MDA-PATC53 cell line
Concentration:	0.51 μM
Incubation Time:	24 hours
Result:	Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.

分子量

555.98

Formula

C₂₈H₂₅ClF₃N₅O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.